Affordable Access

Dominant lethal study of alpha-asarone in male and female mice after sub-chronic treatment.

Authors
  • Chamorro, G
  • Salazar, M
  • Tamariz, J
  • Díaz, F
  • Labarrios, F
Type
Published Article
Journal
Phytotherapy research : PTR
Publication Date
Jun 01, 1999
Volume
13
Issue
4
Pages
308–311
Identifiers
PMID: 10404537
Source
Medline
License
Unknown

Abstract

Dominant lethal studies were conducted in male and female mice with alpha-asarone, the active hypolipidaemic component of Guatteria gaumeri Greenman, by per os sub-chronic treatment (10 and 20 mg/kg, 5 days/week, for 8 weeks) and subsequent mating. alpha-Asarone did not produce germinal mutations in either males or females. Epididymal sperm examination of male mice immediately after treatment failed to reveal any alteration in sperm count on shape. No significant alterations were observed in testicular or epididymal weights or testicular histology.

Report this publication

Statistics

Seen <100 times