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Dominance of the inactive Asian variant over activity and protein contents of mitochondrial aldehyde dehydrogenase 2 in human liver.

Authors
  • Lai, Ching-Long
  • Yao, Chung-Tay
  • Chau, Gar-Yang
  • Yang, Li-Fang
  • Kuo, Tai-Yu
  • Chiang, Chien-Ping
  • Yin, Shih-Jiun
Type
Published Article
Journal
Alcoholism Clinical and Experimental Research
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jan 01, 2014
Volume
38
Issue
1
Pages
44–50
Identifiers
DOI: 10.1111/acer.12215
PMID: 23909789
Source
Medline
Keywords
License
Unknown

Abstract

These results are in good agreement with those predicted by the model studies, thus providing in vivo evidence for differential impairments of hepatic acetaldehyde oxidation with alcohol metabolism in individuals carrying ALDH2*1/*2 and ALDH2*2/*2 genotypes.

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