Affordable Access

deepdyve-link
Publisher Website

Does serum alkaline phosphatase level really indicate the prognosis in patients with osteosarcoma? A meta-analysis.

Authors
  • Gu, Rui1
  • Sun, Yifu1
  • 1 Department of Orthopaedics, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province 130033, China. , (China)
Type
Published Article
Journal
Journal of cancer research and therapeutics
Publication Date
Jun 01, 2018
Volume
14
Issue
Supplement
Identifiers
DOI: 10.4103/0973-1482.177217
PMID: 29970708
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Osteosarcoma is the most common malignant bone tumor that occurs in children and adolescents. Various studies have investigated the role of serum alkaline phosphatase (ALP) level in patients with osteosarcoma but report conflicting findings. Thus, a meta-analysis to assess its prognostic value more precisely is conducted. Pooled hazard ratio (HR) with 95% confidence intervals (CIs) of overall survival (OS) was used to assess the prognostic role of serum ALP level. Eleven studies published between 1993 and 2013 with a total of 1336 osteosarcoma patients were included. Overall, the pooled HR for all 11 eligible studies evaluating high ALP level on OS was 1.60 (95% CI: 1.38-1.86). Sensitivity analysis suggested that the pooled HR was stable and omitting a single study did not change the significance of the pooled HR. Begg's (0.553) and Egger's (0.382) test also did not suggest evidence for publication bias. This meta-analysis suggests that high serum ALP level is obviously associated with lower OS rate in patients with osteosarcoma, and it is an effective biomarker of prognosis.

Report this publication

Statistics

Seen <100 times