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[Does the sampling locality influence on the antifungal activity of the flavonoids of Marrubium vulgare against Aspergillus niger and Candida albicans?].

Authors
  • Bouterfas, K1
  • Mehdadi, Z2
  • Aouad, L3
  • Elaoufi, M M4
  • Khaled, M B4
  • Latreche, A2
  • Benchiha, W2
  • 1 Laboratoire de biodiversité végétale : conservation et valorisation, faculté des sciences de la nature et de la vie, université Djillali Liabes, BP 89, Haï Larbi Ben M'hidi, 22000 Sidi Bel-Abbés, Algérie; Département de l'environnement, faculté des sciences de la nature et de la vie, université Djillali Liabes, 22000 Sidi Bel-Abbés, Algérie. Electronic address: [email protected]
  • 2 Laboratoire de biodiversité végétale : conservation et valorisation, faculté des sciences de la nature et de la vie, université Djillali Liabes, BP 89, Haï Larbi Ben M'hidi, 22000 Sidi Bel-Abbés, Algérie; Département de l'environnement, faculté des sciences de la nature et de la vie, université Djillali Liabes, 22000 Sidi Bel-Abbés, Algérie.
  • 3 Faculté de médecine, université Djillali Liabès, 22000 Sidi Bel-Abbés, Algérie.
  • 4 Laboratoire de biotoxicologie, faculté des sciences de la nature et de la vie, université Djillali Liabes, 22000 Sidi Bel-Abbés, Algérie.
Type
Published Article
Journal
Journal de mycologie medicale
Publication Date
Sep 01, 2016
Volume
26
Issue
3
Pages
201–211
Identifiers
DOI: 10.1016/j.mycmed.2016.02.019
PMID: 26994761
Source
Medline
Keywords
Language
French
License
Unknown

Abstract

The study was undertaken to determine the effect of the sampling locality on the antifungal activity of the flavonoids extracted from the leaves of Marrubium vulgare L. against two fungal strains; Aspergillus niger ATCC 16404 and Candida albicans ATCC 10231. The leaves were collected from three different sampling localities belonging northwest Algeria: Tessala mount, M'sila forest and Ain Skhouna. The flavonoid extraction was carried out by using organic solvents with increasing polarity. A phytochemical screening was performed by staining test tubes. The inhibition diameters were measured by solid medium diffusion method. The minimum inhibitory concentrations were determined by dilution method on solid medium. The antifungal activity varied significantly (P<0.001) according to the sampling locality of the leaves, the flavonoid extract and its concentration, and the strain fungal type. The inhibition diameters varied between 8.16 and recorded 37.5mm even recording a total inhibition of fungal growth and often exceed those induced marketed antifungals (Amphotericin, Fluconazole, Terbinafine and econazole nitrate). The minimum inhibitory concentrations (MICs) obtained range between 6.25 and 100μg/mL; experiencing strong antifungal inhibition. The phytochemical screening revealed the existence of certain flavonoids classes such as flavans and flavanols which may be responsible of this remarkable antifungal power. The sampling locality of Marrubium vulgare leaves influenced on the antifungal activity of flavonoids. These have proven very good fungistatic and worth valuing in pharmacology. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

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