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Does a prediction model for pregnancy of unknown location developed in the UK validate on a US population?

Authors
  • Barnhart, K T
  • Sammel, M D
  • Appleby, D
  • Rausch, M
  • Molinaro, T
  • Van Calster, B
  • Kirk, E
  • Condous, G
  • Van Huffel, S
  • Timmerman, D
  • Bourne, T
Type
Published Article
Journal
Human Reproduction
Publisher
Oxford University Press
Publication Date
Oct 01, 2010
Volume
25
Issue
10
Pages
2434–2440
Identifiers
DOI: 10.1093/humrep/deq217
PMID: 20716562
Source
Medline
License
Unknown

Abstract

A logistic regression model based on two hCG values performed with modest decreases in predictive ability in a US cohort for women at risk for EP compared with the original UK population. However, the sensitivity for EP was too low for the model to be used in clinical practice in its present form. Our data illustrate the difficulties of applying algorithms from one center to another, where the definitions of pathology may differ.

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