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Does Dimeric Melittin Occur in Aqueous Solutions?

Authors
  • D. Schubert
  • G. Pappert
  • K. Boss
Publication Date
Aug 01, 1985
Source
PMC
Keywords
Disciplines
  • Mathematics
License
Unknown

Abstract

Melittin, a peptide from bee venom, is known to undergo a monomer / tetramer conversion in aqueous solutions. We have studied the possible participation of dimers in the association equilibrium of melittin by sedimentation equilibrium experiments in the analytical ultracentrifuge and subsequent mathematical analysis of the concentration distributions obtained. It was found that the dimeric state is not significantly populated, the contribution of dimer to the total peptide weight probably being below 0.5%.

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