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Does cumulative prostate cancer length (CCL) in prostate biopsies improve prediction of clinically insignificant cancer at radical prostatectomy in patients eligible for active surveillance?

Authors
  • Chen, Derrick J
  • Falzarano, Sara M
  • McKenney, Jesse K
  • Przybycin, Chris G
  • Reynolds, Jordan P
  • Roma, Andres
  • Jones, J Stephen
  • Stephenson, Andrew
  • Klein, Eric
  • Magi-Galluzzi, Cristina
Type
Published Article
Journal
British Journal of Urology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Aug 01, 2015
Volume
116
Issue
2
Pages
220–229
Identifiers
DOI: 10.1111/bju.12880
PMID: 25060664
Source
Medline
Keywords
License
Unknown

Abstract

In patients eligible for AS, a CCL/core of <0.20 mm was significantly associated with insignificant cancer and LV-OCD. However, when parameters of cancer burden were considered, CCL/core did not independently add any additional value for predicting insignificant cancer in patients with biopsy Gleason score 6. The CCL/core was an independent predictor of LV-OCD in the whole population and in group 1 patients, although the model including prostate cancer length showed slightly higher area under the receiver operating characteristic curve.

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