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Does central obesity reflect "Cushing's disease of the omentum"?

Authors
Type
Published Article
Journal
Lancet (London, England)
Publication Date
Volume
349
Issue
9060
Pages
1210–1213
Identifiers
PMID: 9130942
Source
Medline
License
Unknown

Abstract

Adipose stromal cells from omental fat, but not subcutaneous fat, can generate active cortisol from inactive cortisone through the expression of 11 beta-HSD1. The expression of this enzyme is increased further after exposure to cortisol and insulin. In vivo, such a mechanism would ensure a constant exposure of glucocorticoid specifically to omental adipose tissue, suggesting that central obesity may reflect "Cushing's disease of the omentum".

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