Affordable Access

Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: an effect reversed by thyroxine pretreatment.

Authors
  • Pantos, Constantinos
  • Mourouzis, Iordanis
  • Tzeis, Stylianos
  • Moraitis, Panagiotis
  • Malliopoulou, Vassiliki
  • Cokkinos, Demosthenis D
  • Carageorgiou, Hariclia
  • Varonos, Dennis
  • Cokkinos, Dennis
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Jan 24, 2003
Volume
460
Issue
2-3
Pages
155–161
Identifiers
PMID: 12559376
Source
Medline
License
Unknown

Abstract

The present study has investigated the effects of dobutamine on postischaemic dysfunction in the setting of global ischaemia and reperfusion in a model of isolated heart preparation. Isolated rat hearts were subjected to 20 min of zero-flow global ischaemia followed by 45 min of reperfusion. Dobutamine administration (10 microg/kg/min) during the reperfusion period resulted in deterioration of functional recovery, which was abolished by propranolol administration. Long-term thyroxine pretreatment (12.5 microg 100 g(-1) body weight, b.i.d., s.c., for 2 weeks) reversed the detrimental effect of dobutamine and increased postischaemic recovery of function. We conclude that the combination of thyroxine pretreatment and dobutamine administration could potentially be a new therapeutic strategy to improve postischaemic dysfunction particularly in clinical settings such as cardiopulmonary bypass and/or myocardial infarction.

Report this publication

Statistics

Seen <100 times