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Do statins induce or protect from acute kidney injury and chronic kidney disease: An update review in 2018

Authors
  • Verdoodt, An
  • Honore, Patrick M. MD, PhD, FCCM
  • Jacobs, Rita
  • Waele, Elisabeth De
  • Gorp, Viola Van
  • Regt, Jouke De
  • Spapen, Herbert D.
Type
Published Article
Journal
Journal of Translational Internal Medicine
Publisher
De Gruyter Open
Publication Date
Mar 28, 2018
Volume
6
Issue
1
Pages
21–25
Identifiers
DOI: 10.2478/jtim-2018-0005
Source
De Gruyter
Keywords
License
Yellow

Abstract

Statins essentially are cholesterol-lowering drugs that are extensively prescribed for primary and secondary prevention of cardiovascular disease. Compelling evidence suggests that the beneficial effects of statins may not only be due to its ability to control cholesterol levels but also due to a pleiotropic cholesterol-independent anti-inflammatory, antioxidant, endothelial-protective and plaque-stabilizing activity. Along this line, statins may also exert acute and long-term effects on renal function. We present a narrative literature review that summarizes arguments in favor of or against the preventive and/or therapeutic use of statins in kidney-related diseases or complications. We also highlight the ongoing controversy regarding statin therapy in chronic and end-stage kidney disease.

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