Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors?
- Authors
- Type
- Published Article
- Journal
- PeerJ
- Publisher
- PeerJ
- Publication Date
- Jan 01, 2013
- Volume
- 1
- Identifiers
- DOI: 10.7717/peerj.149
- PMID: 24058880
- Source
- Medline
- Keywords
- Language
- English
- License
- Unknown
Abstract
NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein coupled receptors GPR18 and GPR92. Recently, we have described that NA-glycine can also modulate recombinant α1β2γ2 GABAA receptors. Here we characterize in more detail this modulation and investigate the relationship of its binding site with that of the endocannabinoid 2-AG.
