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Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors?

Authors
  • Baur, Roland1
  • Gertsch, Jürg
  • Sigel, Erwin
  • 1 Institute of Biochemistry and Molecular Medicine, University of Bern , Bern , Switzerland. , (Switzerland)
Type
Published Article
Journal
PeerJ
Publisher
PeerJ
Publication Date
Jan 01, 2013
Volume
1
Identifiers
DOI: 10.7717/peerj.149
PMID: 24058880
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein coupled receptors GPR18 and GPR92. Recently, we have described that NA-glycine can also modulate recombinant α1β2γ2 GABAA receptors. Here we characterize in more detail this modulation and investigate the relationship of its binding site with that of the endocannabinoid 2-AG.

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