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Do mineral and corn oil serve as potential endocrine disruptors in the gerbil prostate?

Authors
  • Guerra, Luiz Henrique Alves1
  • Tamarindo, Guilherme Henrique2
  • de Campos, Silvana Gisele Pegorin3
  • Taboga, Sebastião Roberto4
  • Vilamaior, Patricia Simone Leite5
  • 1 Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University - UNESP, São José do Rio Preto, SP, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Department of Functional and Structural Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil. Electronic address: [email protected] , (Brazil)
  • 3 Federal University of São João Del Rei, Central-West Campus, Divinópolis, MG, Brazil. Electronic address: [email protected] , (Brazil)
  • 4 Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University - UNESP, São José do Rio Preto, SP, Brazil; Department of Functional and Structural Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil. Electronic address: [email protected] , (Brazil)
  • 5 Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University - UNESP, São José do Rio Preto, SP, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Reproductive toxicology (Elmsford, N.Y.)
Publication Date
Dec 01, 2019
Volume
90
Pages
141–149
Identifiers
DOI: 10.1016/j.reprotox.2019.09.004
PMID: 31568827
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Vegetable oils are frequently used as a vehicle in the administration of lipophilic drugs in animal tests. However, the composition of these oils may interfere with the results. One alternative to reduce this potential bias is the use of mineral oil, which is not supposed to interfere in the physiology of experimental models, since this oil is considered to be innocous. The present study shows for the first time the effects of the oral administration of corn and mineral on the prostate, demonstrating their interference in homeostasis and revealing their potential to act as endocrine disruptors. Mineral oil treatment increased the expression of AR and ERα and serum estradiol concentrations, while corn oil increased the expression of positive cells for both types of estrogen receptors. The variation in the expression of these hormone receptors resulted in morphological changes in the prostate. Copyright © 2019 Elsevier Inc. All rights reserved.

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