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Do lipids shape the eukaryotic cell cycle?

Authors
  • Furse, Samuel1
  • Shearman, Gemma C2
  • 1 NucReg Research Programme, Molekylærbiologisk institutt, Unversitetet i Bergen, Thormøhlens gate 55, 5008, Bergen, Norway; Core Metabolomics and Lipidomics Laboratory, Department of Biochemistry, University of Cambridge, c/o Level 4, Pathology Building, Addenbrookes Hospital, Cambridge, CB2 0QQ, United Kingdom.. Electronic address: [email protected] , (United Kingdom)
  • 2 Faculty of Science, Engineering and Computing, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
Biochimica et Biophysica Acta
Publisher
Elsevier
Publication Date
Jan 01, 2018
Volume
1863
Issue
1
Pages
9–19
Identifiers
DOI: 10.1016/j.bbalip.2017.09.010
PMID: 28964796
Source
Medline
Keywords
License
Unknown

Abstract

Successful passage through the cell cycle presents a number of structural challenges to the cell. Inceptive studies carried out in the last five years have produced clear evidence of modulations in the lipid profile (sometimes referred to as the lipidome) of eukaryotes as a function of the cell cycle. This mounting body of evidence indicates that lipids play key roles in the structural transformations seen across the cycle. The accumulation of this evidence coincides with a revolution in our understanding of how lipid composition regulates a plethora of biological processes ranging from protein activity through to cellular signalling and membrane compartmentalisation. In this review, we discuss evidence from biological, chemical and physical studies of the lipid fraction across the cell cycle that demonstrate that lipids are well-developed cellular components at the heart of the biological machinery responsible for managing progress through the cell cycle. Furthermore, we discuss the mechanisms by which this careful control is exercised.

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