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Do high doses of stimulants impair flexible thinking in attention-deficit hyperactivity disorder?

Authors
  • Douglas, V I
  • Barr, R G
  • Desilets, J
  • Sherman, E
Type
Published Article
Journal
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier
Publication Date
Jul 01, 1995
Volume
34
Issue
7
Pages
877–885
Identifiers
PMID: 7649958
Source
Medline
License
Unknown

Abstract

Under the acute dosage conditions used in this study, MPH doses up to 0.9 mg/kg had an increasingly positive effect on measures of mental flexibility and other cognitive processes. Rather than eliciting perseveration, MPH appeared to improve persistence. The generalized nature of the cognitive and motivational changes observed suggests that MPH acts on central, self-regulatory processes. Because effects of two or more daily doses can accumulate when MPH is prescribed in the clinical situation, clinical doses of more than 0.6 mg/kg were not recommended.

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