The overall CYP3A activity was approximately 50% lower in HIV-infected patients than in healthy volunteers. The CYP2D6 activity was highly variable, but, on average was not different between groups, whereas a marginally lower P-glycoprotein activity was observed in treatment-naive HIV-infected patients.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/21041912