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Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?

Authors
  • Jetter, Alexander
  • Fätkenheuer, Gerd
  • Frank, Dorothee
  • Klaassen, Tobias
  • Seeringer, Angela
  • Doroshyenko, Oxana
  • Kirchheiner, Julia
  • Hein, Wolfgang
  • Schömig, Edgar
  • Fuhr, Uwe
  • Wyen, Christoph
Type
Published Article
Journal
Antiviral Therapy
Publisher
International Medical Press
Publication Date
Jan 01, 2010
Volume
15
Issue
7
Pages
975–983
Identifiers
DOI: 10.3851/IMP1648
PMID: 21041912
Source
Medline
License
Unknown

Abstract

The overall CYP3A activity was approximately 50% lower in HIV-infected patients than in healthy volunteers. The CYP2D6 activity was highly variable, but, on average was not different between groups, whereas a marginally lower P-glycoprotein activity was observed in treatment-naive HIV-infected patients.

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