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DNA tumor viruses — the spies who lyse us.

Authors
Type
Published Article
Journal
Current Opinion in Genetics & Development
Publisher
Elsevier
Volume
15
Issue
1
Pages
18–26
Source
O'Shea Lab
License
Unknown

Abstract

Identifying the molecular lesions that are mission critical for tumorigenesis and maintenance is one of the burning questions in contemporary cancer biology. In addition, therapeutic strategies that trigger the lytic and selective death of tumor cells are the unfulfilled promise of cancer research. Fortunately, viruses can provide not only the necessary intelligence to identify the critical players in the cancer cell program but also have great potential as lytic agents for tumor therapy. Recent studies with DNA viruses have contributed to our understanding of critical tumor targets (such as EGFR, PP2A, Rb and p53) and have an impact on the development of novel therapies, including oncolytic viral agents, for the treatment of cancer.

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