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[DNA repair and tumour radiosensitivity: focus on ATM gene].

Authors
Type
Published Article
Journal
Bulletin du Cancer
0007-4551
Publisher
Elsevier
Publication Date
Volume
98
Issue
3
Pages
239–246
Identifiers
DOI: 10.1684/bdc.2011.1324
PMID: 21466987
Source
Medline

Abstract

Numerous parameters influenced tumour radiosensitivity. The number of clonogenic cells, growth fraction, hypoxia and intrinsic radiosensitivity are among the most important determinants of radiocurability. Detection of DNA damage and repair pathways are important components of intrinsic radiosensitivity. ATM plays a major role in the cellular response to ionizing radiation: it induced DNA repair, cell cycle arrest, and apoptosis via induction of p53. Analysis of single nucleotide polymorphisms could help us to predict normal tissue sensitivity on an individual basis. Mutations of ATM is probably involved in some cases of severe radiation-induced late effects. Measure of residual double-strand breaks by immunochemistry of H2AX, but also ATM or MRE11, is another way to evaluate tumour radiosensitivity. Integration of genomics and functional approach are needed to better predict what the best candidates for a curative radiotherapy are.

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