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DNA repair defects in cancer and therapeutic opportunities.

Authors
  • Hopkins, Jessica L1
  • Lan, Li1, 2
  • Zou, Lee1, 3
  • 1 Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
  • 2 Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
  • 3 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Type
Published Article
Journal
Genes & development
Publication Date
Mar 01, 2022
Volume
36
Issue
5-6
Pages
278–293
Identifiers
DOI: 10.1101/gad.349431.122
PMID: 35318271
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

DNA repair and DNA damage signaling pathways are critical for the maintenance of genomic stability. Defects of DNA repair and damage signaling contribute to tumorigenesis, but also render cancer cells vulnerable to DNA damage and reliant on remaining repair and signaling activities. Here, we review the major classes of DNA repair and damage signaling defects in cancer, the genomic instability that they give rise to, and therapeutic strategies to exploit the resulting vulnerabilities. Furthermore, we discuss the impacts of DNA repair defects on both targeted therapy and immunotherapy, and highlight emerging principles for targeting DNA repair defects in cancer therapy. © 2022 Hopkins et al.; Published by Cold Spring Harbor Laboratory Press.

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