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DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems.

Authors
Type
Published Article
Journal
Angewandte Chemie International Edition in English
1521-3773
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
51
Issue
29
Pages
7176–7180
Identifiers
DOI: 10.1002/anie.201201928
PMID: 22684777
Source
Medline
License
Unknown

Abstract

Dye-ing to live: Spectral limitations of common organic dyes make it difficult or impossible to visualize and follow multiple biological components in rapidly moving systems. The development of a multispectral set of improved DNA-scaffolded fluorophores is described. Their use in multicolor cellular imaging (see scheme) and in tracking of biological motions on the subsecond timescale is demonstrated.

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