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DNA origami signposts for identifying proteins on cell membranes by electron cryotomography

Authors
  • Silvester, Emma1, 2, 3
  • Vollmer, Benjamin1, 3
  • Pražák, Vojtěch1, 3
  • Vasishtan, Daven1, 3
  • Machala, Emily A.1
  • Whittle, Catheryne1
  • Black, Susan1, 3
  • Bath, Jonathan2
  • Turberfield, Andrew J.2
  • Grünewald, Kay1, 3, 4
  • Baker, Lindsay A.1, 3
  • 1 Oxford Particle Imaging Centre, Division of Structural Biology, University of Oxford, Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford UK OX3 7BN
  • 2 Department of Physics, University of Oxford, Clarendon Laboratory, Parks Road, Oxford UK OX1 3PU
  • 3 Centre for Structural Systems Biology, Heinrich-Pette-Institut, Leibniz-Institut für Experimentelle Virologie, Notkestrasse 85, 22607 Hamburg, Germany
  • 4 Department of Chemistry, University of Hamburg, Martin-Luther-King Platz 6, 20146 Hamburg, Germany
Type
Published Article
Journal
Cell
Publisher
Cell Press
Publication Date
Feb 18, 2021
Volume
184
Issue
4
Pages
1110–1121
Identifiers
DOI: 10.1016/j.cell.2021.01.033
PMID: 33606980
PMCID: PMC7895908
Source
PubMed Central
Keywords
License
Unknown

Abstract

Large, folded DNA structures, designed to recognize proteins on cell surfaces, facilitate in situ structural analyses.

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