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DNA methylation and potential multigenerational epigenetic effects linked to uranium chronic low-dose exposure in gonads of males and females rats.

Authors
  • Elmhiri, G1
  • Gloaguen, C1
  • Grison, S1
  • Kereselidze, D1
  • Elie, C1
  • Tack, K1
  • Benderitter, M2
  • Lestaevel, P1
  • Legendre, A1
  • Souidi, M3
  • 1 Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France. , (France)
  • 2 Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France. , (France)
  • 3 Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Toxicology letters
Publication Date
Jan 05, 2018
Volume
282
Pages
64–70
Identifiers
DOI: 10.1016/j.toxlet.2017.10.004
PMID: 29024790
Source
Medline
Keywords
License
Unknown

Abstract

Altogether, our work demonstrates for the first time a sex-dependance and inheritance of epigenetic marks, DNA methylation, as a biological response to the exposure to low doses of uranium. However, it is not clear which type of reproductive cell type is more responsive in this context.

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