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DNA gyrase inhibitory activity of ellagic acid derivatives.

Authors
  • Weinder-Wells, M A
  • Altom, J
  • Fernandez, J
  • Fraga-Spano, S A
  • Hilliard, J
  • Ohemeng, K
  • Barrett, J F
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 06, 1998
Volume
8
Issue
1
Pages
97–100
Identifiers
PMID: 9871636
Source
Medline
License
Unknown

Abstract

Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed.

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