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DNA Damage Response in Nucleoli

Authors
  • Velichko, A. K.1, 2, 3
  • Razin, S. V.1
  • Kantidze, O. L.1
  • 1 Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia , Moscow (Russia)
  • 2 Sechenov First Moscow State Medical University, Moscow, 119146, Russia , Moscow (Russia)
  • 3 Center of Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia , Moscow (Russia)
Type
Published Article
Journal
Molecular Biology
Publisher
Pleiades Publishing
Publication Date
Mar 01, 2021
Volume
55
Issue
2
Pages
182–192
Identifiers
DOI: 10.1134/S002689332102014X
Source
Springer Nature
Keywords
License
Yellow

Abstract

AbstractNucleoli, the largest subnuclear compartments, are formed around arrays of ribosomal gene repeats transcribed by RNA polymerase I. The primary function of nucleoli is ribosome biogenesis. Specific DNA damage response mechanisms exist to maintain the genomic stability of ribosomal repeats. Here, we provide a snapshot of our current understanding of processes involved in nucleolar DNA damage response. We discuss structure and function of ribosomal repeats, techniques developed for studying DNA damage response in nucleoli, as well as molecular mechanisms of DNA damage-induced repression of nucleolar transcription and nucleoli reorganization.

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