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D-lactic acidosis in humans: systematic literature review.

Authors
  • Bianchetti, Davide G A M1
  • Amelio, Giacomo S2
  • Lava, Sebastiano A G3
  • Bianchetti, Mario G4
  • Simonetti, Giacomo D1
  • Agostoni, Carlo2
  • Fossali, Emilio F2
  • Milani, Gregorio P2
  • 1 Pediatric Department of Southern Switzerland, Bellinzona, and Università della Svizzera Italiana, Lugano, Switzerland. , (Switzerland)
  • 2 Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. , (Italy)
  • 3 Department of Pediatrics, University Children's Hospital of Bern, Inselspital, Bern, Switzerland. , (Switzerland)
  • 4 Pediatric Department of Southern Switzerland, Bellinzona, and Università della Svizzera Italiana, Lugano, Switzerland. [email protected] , (Switzerland)
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Apr 01, 2018
Volume
33
Issue
4
Pages
673–681
Identifiers
DOI: 10.1007/s00467-017-3844-8
PMID: 29218437
Source
Medline
Keywords
License
Unknown

Abstract

In humans with short bowel syndrome (or carbohydrate malabsorption), D-lactic acidosis is likely rather common and under-recognized. This condition should be included in the differential diagnosis of unexplained high-gap metabolic acidosis where the anion causing the acidosis is not known. Furthermore, diabetic acidosis might be caused by accumulation of both ketone bodies and D-lactic acid. Finally, there are endogenous sources of D-lactic acid in subjects with propylene glycol intoxication.

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