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The Diverse Contributions of Fucose Linkages in Cancer

Authors
  • Keeley, Tyler S.1, 2, 3
  • Yang, Shengyu1
  • Lau, Eric3
  • 1 Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA
  • 2 University of South Florida Cancer Biology Graduate Program, Tampa, FL 33602, USA
  • 3 Department of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL 33602, USA
Type
Published Article
Journal
Cancers
Publisher
MDPI AG
Publication Date
Aug 24, 2019
Volume
11
Issue
9
Identifiers
DOI: 10.3390/cancers11091241
PMID: 31450600
PMCID: PMC6769556
Source
PubMed Central
Keywords
License
Green

Abstract

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.

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