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Divergent approach for synthesis and terminal modifications of dendritic polyphenylazomethines.

Authors
  • Takanashi, Kensaku
  • Yamamoto, Kimihisa
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Dec 06, 2007
Volume
9
Issue
25
Pages
5151–5154
Identifiers
PMID: 17997561
Source
Medline
License
Unknown

Abstract

In the past, dendritic polyphenylazomethines (DPA) have been synthesized via the convergent method. However, the convergent method has problems such as difficult terminal-group modifications and an increased number of steps. Therefore, we synthesized the terminal-protected DPA to construct the dendritic structure via the divergent method. The combination of the convergent method and the divergent method easily achieved the rapid synthesis of a higher generation dendrimer. Furthermore, we succeeded in the synthesis of the water-soluble PEG-DPA via the divergent method using the ester-DPA.

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