Divergent approach for synthesis and terminal modifications of dendritic polyphenylazomethines.
- Published Article
American Chemical Society
- Publication Date
Dec 06, 2007
In the past, dendritic polyphenylazomethines (DPA) have been synthesized via the convergent method. However, the convergent method has problems such as difficult terminal-group modifications and an increased number of steps. Therefore, we synthesized the terminal-protected DPA to construct the dendritic structure via the divergent method. The combination of the convergent method and the divergent method easily achieved the rapid synthesis of a higher generation dendrimer. Furthermore, we succeeded in the synthesis of the water-soluble PEG-DPA via the divergent method using the ester-DPA.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/17997561