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Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells.

Authors
  • Peters, J A1
  • Hales, T G
  • Lambert, J J
  • 1 Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital, University of Dundee, U.K.
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Jul 14, 1988
Volume
151
Issue
3
Pages
491–495
Identifiers
PMID: 2463926
Source
Medline
License
Unknown

Abstract

The influence of extracellular calcium and magnesium ion concentrations upon 5-HT3 receptor-gated membrane currents in murine N1E-115 neuroblastoma cells has been studied under voltage-clamp conditions. A decrease in the concentration of either Ca2+ or Mg2+ from their standard values of 1.0 and 2.0 mM respectively augmented both the amplitude and duration of the 5-HT-induced current, whereas elevating the concentration of either divalent cation produced the opposite effect. Such modulation did not involve a change in the reversal potential of the response.

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