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Diurnal variation in melatonin effect on adenosine triphosphate and serotonin release by human platelets.

Authors
  • Del Zar, M M
  • Martinuzzo, M
  • Cardinali, D P
  • Carreras, L O
  • Vacas, M I
Type
Published Article
Journal
Acta endocrinologica
Publication Date
Oct 01, 1990
Volume
123
Issue
4
Pages
453–458
Identifiers
PMID: 2239090
Source
Medline
License
Unknown

Abstract

The effect of the pineal hormone melatonin on adenosine diphosphate-induced human platelet aggregation and adenosine triphosphate release was assessed in platelet-rich plasma obtained from normal volunteers at 08.30 and 20.30 h. In 10(-7)-10(-5) mol/l concentrations melatonin inhibited ADP-induced platelet aggregation only in the evening (p less than 0.05). ADP-induced ATP release, an index of platelet secretory processes, showed a generally greater, dose-dependent inhibition after adding melatonin (10(-9)-10(-5)mol/l) at 20.30 h as compared with 08.30 h. The inhibitory activity of melatonin (10(-9)-10(-5) mol/l) on [3H]serotonin release elicited by thrombin in washed human platelets obtained from normal volunteers was dose-dependent; the effect was generally greater at 20.30 h. The activity of the potent platelet anti-aggregating agent prostacyclin did not exhibit diurnal differences with respect to impairing ADP-induced platelet-rich plasma aggregation. These results indicate the existence of a diurnal variation of sensitivity to melatonin in human platelets.

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