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Diurnal changes in heparin effect during continuous constant-rate infusion. A study in nine patients with venous thromboembolism.

Authors
  • Krulder, J W
  • Van den Besselaar, A M
  • Van der Meer, F J
  • Meinders, A E
  • Briët, E
Type
Published Article
Journal
Journal of internal medicine
Publication Date
May 01, 1994
Volume
235
Issue
5
Pages
411–417
Identifiers
PMID: 8182395
Source
Medline
License
Unknown

Abstract

A continuous intravenous infusion of unfractionated heparin has a maximum anticoagulant effect between 04.00 and 8.00 hours and a minimum effect at noon. For individual patients the moment of minimum and maximum effect varies widely. Because the most impressive changes occur between 06.00 and 08.00 hours, laboratory control can best be performed at fixed times, e.g. at 10.00 and at 22.00 hours.

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