Diurnal changes in heparin effect during continuous constant-rate infusion. A study in nine patients with venous thromboembolism.
- Published Article
Journal of internal medicine
- Publication Date
May 01, 1994
A continuous intravenous infusion of unfractionated heparin has a maximum anticoagulant effect between 04.00 and 8.00 hours and a minimum effect at noon. For individual patients the moment of minimum and maximum effect varies widely. Because the most impressive changes occur between 06.00 and 08.00 hours, laboratory control can best be performed at fixed times, e.g. at 10.00 and at 22.00 hours.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/8182395