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Diterpenoids from the twigs and leaves of Fokienia hodginsii.

Authors
  • 1
  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. , (China)
Type
Published Article
Journal
Journal of Natural Products
1520-6025
Publisher
American Chemical Society
Publication Date
Volume
76
Issue
6
Pages
1032–1038
Identifiers
DOI: 10.1021/np400010c
PMID: 23691952
Source
Medline
License
Unknown

Abstract

Five new isopimarane diterpenoids, fokihodgins A-E (1-5), four new labdane diterpenoids, fokihodgins F-I (6-9), and one new icetexane diterpenoid, fokihodgin J (10), as well as 18 known diterpenoids were isolated from Fokienia hodginsii. The structures of the new compounds were determined on the basis of their spectroscopic analysis, and the absolute configurations of 1 and 6 were established by X-ray crystallographic analysis. Compound 9 showed moderate cytotoxicity against HL-60 and SMMC-7721 cell lines, with IC50 values of 9.10 and 7.50 μM, respectively.

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