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Distribution of Hepatitis B Virus Genotypes in Two Different Pediatric Populations from Argentina

  • V. A. Mbayed
  • J. L. López
  • P. F. S. Telenta
  • G. Palacios
  • I. Badía
  • A. Ferro
  • C. Galoppo
  • R. Campos
American Society for Microbiology
Publication Date
Nov 01, 1998
  • Biology
  • Medicine


Differences in pathogenesis and the probability of becoming a chronic carrier depend on the age at which hepatitis B virus (HBV) infection is acquired, ranging from 82% in infants less than 6 months of age to 15 to 30% in older children. HBV genotypes from 22 pediatric patients from two areas that differ in prevalence have been determined. Phylogenetic analysis shows a clear difference between the genotype distribution in Buenos Aires, a low-prevalence area, and that found in Gualeguay, Entre Ríos, a high-prevalence area. While the analysis allocated the sequences in the Buenos Aires group to genotypes A (36%), D (9%), and F (55%), the Gualeguay group presented exclusively genotype A isolates with very low nucleotide divergence, which suggests a strong founder viral population. The high prevalence of genotype F in the Buenos Aires group and its high intragroup heterogeneity agree with the American origin of this genotype.

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