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Distribution of the multiple molecular forms of glucose-6-phosphate dehydrogenase in different physiological states.

Authors
  • Chang, H L
  • Holten, D
  • Karin, R
Type
Published Article
Journal
Canadian journal of biochemistry
Publication Date
May 01, 1979
Volume
57
Issue
5
Pages
396–401
Identifiers
PMID: 455118
Source
Medline
License
Unknown

Abstract

The distribution of the multiple molecular forms of rat liver and mammary gland glucose-6-phosphate dehydrogenase was determined by electrophoresis on 5% polyacrylamide gels. In both of these organs, changes in the distribution of enzyme activity among the several forms was slight even when approximately 20- to 40-fold changes in enzyme specific activity were achieved by fasting-refeeding experiments (for liver) or during pregnancy and lactation (for mammary gland). It was concluded that the induction of glucose-6-phosphate dehydrogenase in these two organs occurs without any major redistribution among the multiple molecular forms of this enzyme.

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