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The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy.

Authors
  • Brown, P
  • Rohwer, R G
  • Dunstan, B C
  • MacAuley, C
  • Gajdusek, D C
  • Drohan, W N
Type
Published Article
Journal
Transfusion
Publication Date
Sep 01, 1998
Volume
38
Issue
9
Pages
810–816
Identifiers
PMID: 9738619
Source
Medline
License
Unknown

Abstract

Convergent results from exogenous spiking and endogenous infectivity experiments, in which decreasing levels of infectivity occurred in cellular blood components, plasma, and plasma fractions, suggest a potential but minimal risk of acquiring Creutzfeldt-Jakob disease from the administration of human plasma protein concentrates.

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