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Distribution of estrogen receptor in ductal carcinoma in situ of the breast.

Authors
Type
Published Article
Journal
Surgery
0039-6060
Publisher
Elsevier
Publication Date
Volume
113
Issue
2
Pages
134–137
Identifiers
PMID: 8381562
Source
Medline
License
Unknown

Abstract

The incidence of ER in DCIS is similar to the incidence of ER in invasive carcinoma, leading to the speculation that ER-positive invasive carcinoma originates from an ER-positive precursor lesion. Because only 60% of the cases have detectable ER and approximately 70% of positively stained ERs are expected to be functional (as in invasive carcinoma), it appears that approximately 42% of the patient population with DCIS will benefit from antiestrogen therapy.

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