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Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer.

Authors
  • Han, Bo
  • McCarren, Hilary S
  • O'Neill, Dan
  • Kelz, Max B
Type
Published Article
Journal
Anesthesiology
Publication Date
Nov 01, 2014
Volume
121
Issue
5
Pages
999–1009
Identifiers
DOI: 10.1097/ALN.0000000000000383
PMID: 25057841
Source
Medline
License
Unknown

Abstract

Anesthetic unconsciousness is not accompanied by global activation of all putative sleep-promoting neurons. However, within the VLPO hypnotic doses of volatile anesthetics, but not nonimmobilizers, activate putative sleep-promoting neurons, correlating with the appearance of the hypnotic state.

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