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Distinctions between the two-state and sequential models for cooperative ligand binding.

Authors
  • R E Gibson
  • S A Levin
Publication Date
Jan 01, 1977
Source
PMC
Keywords
License
Unknown

Abstract

The two-state and sequential models for positive cooperativity in ligand binding can produce significantly different theoretical binding curves when presented in a Scatchard plot. The conditions that produce the greatest differences have been examined. The theoretical differences have been used to select the two-state model as the best model for describing the binding of acetylcholine to acetylcholine receptors that have been solubilized by Triton X-100 and sodium cholate.

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