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Distinct subcellular localization of tRNA-derived fragments in the infective metacyclic forms of Trypanosoma cruzi.

Authors
  • Reifur, Larissa
  • Garcia-Silva, Maria Rosa
  • Poubel, Saloê Bispo
  • Alves, Lysangela Ronalte
  • Arauco, Paulo
  • Buiar, Diane Kelly
  • Goldenberg, Samuel
  • Cayota, Alfonso
  • Dallagiovanna, Bruno
Type
Published Article
Journal
Memórias do Instituto Oswaldo Cruz
Publisher
SciELO
Publication Date
Sep 01, 2012
Volume
107
Issue
6
Pages
816–819
Identifiers
PMID: 22990974
Source
Medline
License
Unknown

Abstract

Small non-coding RNAs derived from transfer RNAs have been identified as a broadly conserved prokaryotic and eukaryotic response to stress. Their presence coincides with changes in developmental state associated with gene expression regulation. In the epimastigote form of Trypanosoma cruzi, tRNA fragments localize to posterior cytoplasmic granules. In the infective metacyclic form of the parasite, we found tRNA-derived fragments to be abundant and evenly distributed within the cytoplasm. The fragments were not associated with polysomes, suggesting that the tRNA-derived fragments may not be directly involved in translation control in metacyclics.

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