Affordable Access

Distinct proteins interacting with the glucocorticoid receptor.

Authors
  • Schulz, M
  • Zhang, R
  • Eggert, H
  • Boeke, J
  • Neeck, G
  • Eggert, M
  • Renkawitz, R
Type
Published Article
Journal
Zeitschrift für Rheumatologie
Publication Date
Jan 01, 2000
Volume
59 Suppl 2
Identifiers
PMID: 11155805
Source
Medline
License
Unknown

Abstract

The glucocorticoid receptor (GR) is a hormone-dependent transcription factor that modulates gene transcription by binding to its response element, interacting with other transcription factors, contacting the basal transcription machinery and by interacting with several intermediary proteins, such as coactivators. Here we discuss the most prominent examples for interacting transcription factors, interacting proteins that belong to the basal transcription apparatus and intermediary factors. Furthermore, we describe a new class of GR-interacting proteins (GRIPs) which have been identified by a blotting technique, using a radioactively labeled GR/GRE complex as a probe to identify proteins that interact with the activated GR. Two of these GRIPs, termed GRIP170 and GRIP 120, which were identified by biochemical purification and microsequencing and have turned out to play a role in modulating GR-mediated transcription, are discussed in detail.

Report this publication

Statistics

Seen <100 times