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Distinct patterns of mitochondrial genome diversity in bonobos (Pan paniscus) and humans

Authors
  • Zsurka, Gábor1
  • Kudina, Tatiana1
  • Peeva, Viktoriya1
  • Hallmann, Kerstin1
  • Elger, Christian E1
  • Khrapko, Konstantin2
  • Kunz, Wolfram S1
  • 1 University Bonn, Division of Neurochemistry, Department of Epileptology and Life&Brain Center, Sigmund-Freud-Str. 25, Bonn, 53105, Germany , Bonn (Germany)
  • 2 Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA , Boston (United States)
Type
Published Article
Journal
BMC Evolutionary Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Sep 02, 2010
Volume
10
Issue
1
Identifiers
DOI: 10.1186/1471-2148-10-270
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundWe have analyzed the complete mitochondrial genomes of 22 Pan paniscus (bonobo, pygmy chimpanzee) individuals to assess the detailed mitochondrial DNA (mtDNA) phylogeny of this close relative of Homo sapiens.ResultsWe identified three major clades among bonobos that separated approximately 540,000 years ago, as suggested by Bayesian analysis. Incidentally, we discovered that the current reference sequence for bonobo likely is a hybrid of the mitochondrial genomes of two distant individuals. When comparing spectra of polymorphic mtDNA sites in bonobos and humans, we observed two major differences: (i) Of all 31 bonobo mtDNA homoplasies, i.e. nucleotide changes that occurred independently on separate branches of the phylogenetic tree, 13 were not homoplasic in humans. This indicates that at least a part of the unstable sites of the mitochondrial genome is species-specific and difficult to be explained on the basis of a mutational hotspot concept. (ii) A comparison of the ratios of non-synonymous to synonymous changes (dN/dS) among polymorphic positions in bonobos and in 4902 Homo sapiens mitochondrial genomes revealed a remarkable difference in the strength of purifying selection in the mitochondrial genes of the F0F1-ATPase complex. While in bonobos this complex showed a similar low value as complexes I and IV, human haplogroups displayed 2.2 to 7.6 times increased dN/dSratios when compared to bonobos.ConclusionsSome variants of mitochondrially encoded subunits of the ATPase complex in humans very likely decrease the efficiency of energy conversion leading to production of extra heat. Thus, we hypothesize that the species-specific release of evolutionary constraints for the mitochondrial genes of the proton-translocating ATPase is a consequence of altered heat homeostasis in modern humans.

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