Affordable Access

Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.

Authors
Type
Published Article
Journal
The Israel Medical Association journal : IMAJ
Publication Date
Volume
1
Issue
1
Pages
4–7
Identifiers
PMID: 11370121
Source
Medline
License
Unknown

Abstract

ANCAs typically found in active SVV are demonstrable both by indirect immunofluorescence and antigen-specific enzyme immunoassay, and strong reactivity to either PR3 or MPO is characteristic. Strong ANCA with MPO reactivity is also found in some patients with drug-induced syndromes (lupus, vasculitis). Intermediate to strong perinuclear ANCAs are found in a substantial proportion of patients with UC (40-60%) and RA (30-70%), but in these conditions the ANCAs have many antigen targets that are only weakly recognized.

Statistics

Seen <100 times