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Distant Syncytia of Adjacent Neuronal Anastomoses

Authors
  • Sotnikov, O. S.1
  • Davydova, L. A.2
  • 1 Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia , St. Petersburg (Russia)
  • 2 Belarusian State Medical University, Minsk, Belarus , Minsk (Belarus)
Type
Published Article
Journal
Biology Bulletin Reviews
Publisher
Pleiades Publishing
Publication Date
Dec 01, 2021
Volume
11
Issue
Suppl 1
Pages
78–84
Identifiers
DOI: 10.1134/S2079086421070082
Source
Springer Nature
Keywords
Disciplines
  • Article
License
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Abstract

AbstractIt is known that an anastomosis (from Greek) is “an opening connecting tubular structures.” However, the previously described interneuronal, fiber, nonsynaptic connections were usually considered commissural, and their appearance was hypothetically associated with not the usual division but often the repeated division of neuronal nuclei and the growth of neurites connecting them. The goal of our work was to revise this neurobiological hypothesis based on fixed drugs from the perspective of the kinetics of living neurons. It was shown in video that paired connections of neurons form not by cell division but by the fusion of their two nerve processes and bodies. It is shown that the axoplasmic current (gel), which reduces interneuronal commissures, brings the cells together until they merge. It became clear that the fragments of connecting fibers are not just commissural processes; they are a tubular, electrically and tinctorially permeable, retracting, system—an anastomosis. Like any anastomosis, this structure has two terminal perforations, i.e., it is a distant syncytium. As a result of these data, neurites no longer need to be considered an exception to the general biological law on the general basic properties of Ranvier cells. This syncytium was described for the first time only in dendritic cells. Therefore, we analyzed classic neurohistology monographs of Ramon y Cajal. Ubiquitous multiple, distant anastomoses that he had not recognized were found in his works. In our opinion, they should significantly affect the electrical properties of the nervous system need to be supplemented by the general biological theory of the nervous system of multicellular animals.

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