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Dissociable corticostriatal circuits underlie goal-directed vs. cue-elicited habitual food seeking after satiation: evidence from a multimodal MRI study.

Authors
  • van Steenbergen, Henk1, 2
  • Watson, Poppy3, 4
  • Wiers, Reinout W3, 5
  • Hommel, Bernhard1, 2
  • de Wit, Sanne3, 4
  • 1 Leiden Institute for Brain and Cognition, Leiden, The Netherlands. , (Netherlands)
  • 2 Institute of Psychology, Leiden University, Wassenaarseweg 52, 2333, AK Leiden, The Netherlands. , (Netherlands)
  • 3 Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands. , (Netherlands)
  • 4 Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands. , (Netherlands)
  • 5 Addiction Development and Psychopathology (ADAPT) Lab, Department of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands. , (Netherlands)
Type
Published Article
Journal
European Journal of Neuroscience
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jul 01, 2017
Volume
46
Issue
2
Pages
1815–1827
Identifiers
DOI: 10.1111/ejn.13586
PMID: 28444823
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The present multimodal MRI study advances our understanding of the corticostriatal circuits underlying goal-directed vs. cue-driven, habitual food seeking. To this end, we employed a computerized Pavlovian-instrumental transfer paradigm. During the test phase, participants were free to perform learned instrumental responses (left and right key presses) for popcorn and Smarties outcomes. Importantly, prior to this test half of the participants had been sated on popcorn and the other half on Smarties - resulting in a reduced desirability of those outcomes. Furthermore, during a proportion of the test trials, food-associated Pavlovian cues were presented in the background. In line with previous studies, we found that participants were able to perform in a goal-directed manner in the absence of Pavlovian cues, meaning that specific satiation selectively reduced responding for that food. However, presentation of Pavlovian cues biased choice toward the associated food reward regardless of satiation. Functional MRI analyses revealed that, in the absence of Pavlovian cues, posterior ventromedial prefrontal cortex tracked outcome value. In contrast, during cued trials, the BOLD signal in the posterior putamen differentiated between responses compatible and incompatible with the cue-associated outcome. Furthermore, we identified a region in ventral amygdala showing relatively strong functional connectivity with posterior putamen during the cued trials. Structural MRI analyses provided converging evidence for the involvement of corticostriatal circuits: diffusion tensor imaging data revealed that connectivity of caudate-seeded white-matter tracts to the ventromedial prefrontal cortex predicted responding for still-valuable outcomes; and gray matter integrity in the premotor cortex predicted individual Pavlovian cueing effects. © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

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