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Disseminated histoplasmosis in a kidney liver transplant patient from a non-endemic area: A diagnostic challenge

Authors
  • Carmans, L.1
  • Van Craenenbroeck, A.1, 2
  • Lagrou, K.3
  • Deroose, C.M.4
  • Sagaert, X.5
  • Wolthuis, A.6
  • Van Wijngaerden, E.7
  • Kuypers, D.R.1, 2
  • 1 Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
  • 2 Department of Microbiology and Immunology, Catholic University of Leuven, Belgium
  • 3 Department of Laboratory of Clinical Bacteriology and Mycology, University Hospitals Leuven, Belgium
  • 4 Nuclear Medicine & Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Belgium
  • 5 Department of Pathology, University Hospitals Leuven, Belgium
  • 6 Department of Abdominal Surgery, University Hospitals Leuven, Belgium
  • 7 Department of General Internal Medicine and Infectiology, University Hospitals Leuven, Belgium
Type
Published Article
Journal
IDCases
Publisher
Elsevier
Publication Date
Sep 28, 2020
Volume
22
Identifiers
DOI: 10.1016/j.idcr.2020.e00971
PMID: 33088713
PMCID: PMC7566087
Source
PubMed Central
Keywords
License
Unknown

Abstract

Disseminated histoplasmosis is a rare opportunistic infection in non-endemic areas, where the disease is often diagnosed late. The spectrum of clinical manifestations is broad and life-threatening complications occur. We present a detailed case of a kidney liver transplant patient with disseminated histoplasmosis in a non-endemic area. Our case highlights the wide range of pathogens to consider in the immunocompromised patient, the delayed diagnosis of Histoplasmosis Capsulatum in non-endemic areas and the possibility of severe gastrointestinal disease. We also briefly review diagnostic tests and treatment options.

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