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Disseminated Cryptococcosis Due to Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Absence of Pulmonary Alveolar Proteinosis.

Authors
  • Kuo, Chen-Yen1, 2
  • Wang, Shang-Yu1, 3
  • Shih, Han-Po1
  • Tu, Kun-Hua1, 4
  • Huang, Wen-Chi5
  • Ding, Jing-Ya1
  • Lin, Chia-Hao1
  • Yeh, Chun-Fu1, 6
  • Ho, Mao-Wang7, 8
  • Chang, Shi-Chuan9
  • He, Chi-Ying1, 10
  • Chen, Hung-Kai11
  • Ho, Chen-Hsuan11
  • Lee, Chen-Hsiang5
  • Chi, Chih-Yu1, 7, 8
  • Ku, Cheng-Lung12, 13, 14, 15
  • 1 Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan. , (Taiwan)
  • 2 Division of Infectious Diseases, Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. , (Taiwan)
  • 3 Department of Trauma and Emergency Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. , (Taiwan)
  • 4 Department of Nephrology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. , (Taiwan)
  • 5 Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. , (Taiwan)
  • 6 Division of Infectious Diseases, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. , (Taiwan)
  • 7 School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. , (China)
  • 8 Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan. , (China)
  • 9 Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. , (Taiwan)
  • 10 Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan. , (Taiwan)
  • 11 Laboratory of Translational Medicine, Development Center for Biotechnology, New Taipei City, Taiwan. , (Taiwan)
  • 12 Laboratory of Human Immunology and Infectious Disease, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan. [email protected] , (Taiwan)
  • 13 Division of Infectious Diseases, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. [email protected] , (Taiwan)
  • 14 Graduate Institute of Clinical Medical Sciences, China Medical University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan City, 333, Taiwan. [email protected] , (China)
  • 15 Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan. [email protected] , (Taiwan)
Type
Published Article
Journal
Journal of Clinical Immunology
Publisher
Springer-Verlag
Publication Date
Feb 01, 2017
Volume
37
Issue
2
Pages
143–152
Identifiers
DOI: 10.1007/s10875-016-0364-4
PMID: 28013480
Source
Medline
Keywords
License
Unknown

Abstract

Anti-GM-CSF autoantibodies increase susceptibility to cryptococcal infection in adults without PAP. Cryptococcal central nervous system infection associated with anti-GM-CSF autoantibodies could result in neurological sequelae or be life-threatening. Therefore, timely detection of neutralizing anti-GM-CSF autoantibodies and development of an effective therapy are necessary to prevent deterioration of cryptococcal infection in these patients.

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