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Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.

Authors
  • Pasparakis, M1
  • Luedde, T
  • Schmidt-Supprian, M
  • 1 European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini 32, Monterotondo-Scalo, Rome 00016, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Cell Death and Differentiation
Publisher
Springer Nature
Publication Date
May 01, 2006
Volume
13
Issue
5
Pages
861–872
Identifiers
PMID: 16470223
Source
Medline
License
Unknown

Abstract

Studies in transgenic and knockout mice have made a major contribution to our current understanding of the physiological functions of the NF-kappaB signalling cascade. The generation and analysis of mice with targeted modifications of individual components of the NF-kappaB pathway tremendously advanced our knowledge of the roles of the NF-kappaB proteins themselves, and also of the many activators and negative regulators of NF-kappaB. These studies have highlighted the complexity of the NF-kappaB system, by revealing the multiple interactions, redundancies, but also diverse functions, performed by the different molecules participating in the regulation of NF-kappaB signalling. Furthermore, inhibition or enforced activation of NF-kappaB in transgenic mice has uncovered the critical roles that NF-kappaB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer.

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