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Dissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotency

Authors
  • Lee, Young Jin1
  • Ramakrishna, Suresh2, 3
  • Chauhan, Himanshu4
  • Park, Won Sun5
  • Hong, Seok-Ho6, 7
  • Kim, Kye-Seong2, 3
  • 1 MizMedi Women’s Hospital, iDream Research Center, Seoul, 07639, South Korea , Seoul (South Korea)
  • 2 Hanyang University, Department of Biomedical Science, Graduate School of Biomedical Science and Engineering, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea , Seoul (South Korea)
  • 3 Hanyang University, College of Medicine, Seoul, South Korea , Seoul (South Korea)
  • 4 Uppsala University, Uppsala, 75236, Sweden , Uppsala (Sweden)
  • 5 Kangwon National University, Department of Physiology, School of Medicine, Chuncheon, 24341, South Korea , Chuncheon (South Korea)
  • 6 Kangwon National University, Department of Internal Medicine, School of Medicine, 1 Kangwondaehak-gil, Chuncheon-si, Gangwon-do, 24341, South Korea , Chuncheon-si (South Korea)
  • 7 Kangwon National University, Stem Cell Institute, Chuncheon, 24341, South Korea , Chuncheon (South Korea)
Type
Published Article
Journal
Cell Regeneration
Publisher
BioMed Central
Publication Date
Mar 22, 2016
Volume
5
Issue
1
Identifiers
DOI: 10.1186/s13619-016-0028-0
Source
Springer Nature
Keywords
License
Green

Abstract

Increasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19–24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional level. Embryonic stem cells (ESCs) represent a valuable tool for disease modeling, drug discovery, developmental studies, and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and pluripotency. Therefore, remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of pluripotency. Here, we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming, as well as the potential role of miRNAs in two distinct pluripotent states (naïve and primed).

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