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Disruptive effect of diethylstilbestrol on microtubules.

Authors
  • Sato, Y
  • Murai, T
  • Tsumuraya, M
  • Saitô, H
  • Kodama, M
Type
Published Article
Journal
Gan
Publication Date
Dec 01, 1984
Volume
75
Issue
12
Pages
1046–1048
Identifiers
PMID: 6526218
Source
Medline
License
Unknown

Abstract

Diethylstilbestrol, a unique carcinogen lacking measurable mutagenic potency in Salmonella, was shown to be an inhibitor of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The effective concentration of diethylstilbestrol was 10-200 microM, as determined by viscometry, turbidity measurement, and electron microscopic analysis.

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