Disruptive effect of diethylstilbestrol on microtubules.

Y Sato; T Murai; M Tsumuraya; H Saitô; M Kodama

Disruptive effect of diethylstilbestrol on microtubules.

Authors

Sato, Y
Murai, T
Tsumuraya, M
Saitô, H
Kodama, M

Type

Published Article

Journal

Gan

Publication Date

Dec 01, 1984

Volume

75

Issue

12

Pages

1046–1048

Identifiers

PMID: 6526218

Source

Medline

License

Unknown

Abstract

Diethylstilbestrol, a unique carcinogen lacking measurable mutagenic potency in Salmonella, was shown to be an inhibitor of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The effective concentration of diethylstilbestrol was 10-200 microM, as determined by viscometry, turbidity measurement, and electron microscopic analysis.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/01/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6526218

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