Affordable Access

Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses.

Authors
  • Rodig, S J
  • Meraz, M A
  • White, J M
  • Lampe, P A
  • Riley, J K
  • Arthur, C D
  • King, K L
  • Sheehan, K C
  • Yin, L
  • Pennica, D
  • Johnson, E M Jr
  • Schreiber, R D
Type
Published Article
Journal
Cell
Publisher
Elsevier
Publication Date
May 01, 1998
Volume
93
Issue
3
Pages
373–383
Identifiers
PMID: 9590172
Source
Medline
License
Unknown

Abstract

Herein we report the generation of mice lacking the ubiquitously expressed Janus kinase, Jak1. Jak1-/- mice are runted at birth, fail to nurse, and die perinatally. Although Jak1-/- cells are responsive to many cytokines, they fail to manifest biologic responses to cytokines that bind to three distinct families of cytokine receptors. These include all class II cytokine receptors, cytokine receptors that utilize the gamma(c) subunit for signaling, and the family of cytokine receptors that depend on the gp130 subunit for signaling. Our results thus demonstrate that Jak1 plays an essential and nonredundant role in promoting biologic responses induced by a select subset of cytokine receptors, including those in which Jak utilization was thought to be nonspecific.

Report this publication

Statistics

Seen <100 times