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Disordered beta-catenin expression and E-cadherin/CDH1 promoter methylation in gastric carcinoma.

Authors
  • Wang, Li
  • Zhang, Fan
  • Wu, Ping-Ping
  • Jiang, Xu-Cheng
  • Zheng, Lin
  • Yu, Ying-Yan
Type
Published Article
Journal
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Co
Publication Date
Jul 14, 2006
Volume
12
Issue
26
Pages
4228–4231
Identifiers
PMID: 16830381
Source
Medline
License
Unknown

Abstract

Comparative analysis of nuclear and membrane/cytoplasmic beta-catenin can predict local tumor infiltration. E-cadherin/CDH1 gene methylation is an important cause for its gene silence in diffuse variant gastric carcinoma. Methylation of CDH1 gene in the absence of E-cadherin is an early event in gastric carcinogenesis.

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