To ensure patient safety and improve clinical outcomes, pharmacist care protocols must be put in place to detect potential drug-related problems (DRP) and negative outcomes associated with medication (NOM) each time drugs are dispensed. Some consensus has been reached about the aims and requirements of such protocols, but as yet no study has measured their results.The aim of this study was to design and pilot such a protocol for drug dispensing. The study design was based on the aims and requirements set out in the Spanish Ministry of Health's Consensus Document on Pharmaceutical Care. A literature review was carried out and qualitative consensus-seeking techniques were used. For the pilot trial, a cross-sectional study was carried out in 53 community pharmacies in 24 Spanish provinces. The protocol designed is a useful tool for detecting any drug-related information gaps that patients may have, as well as potential DRP and NOM.